Endocrine Abstracts

The PREDIMED trial showed that long-term adherence to an ad libitum Mediterranean diet (MeDiet) supplemented with extra-virgin olive oil (EVOO) or mixed nuts reduced incident cardiovascular disease (CVD) in older subjects at high risk. No clinical trials have been conducted to demonstrate whether weight loss sustained over time with an energy-restricted healthy diet plus increased physical activity (PA) reduces CVD risk. We designed the PREDIMED-PLUS study, a 6-year, multicent...